Talent Tree Combination Size
Full talent tree sims are not possible on Raidbots and may never be due to their immense size.
The average size for just a full spec tree sim (not touching the class side at all) is about 60 million combinations which is about 300 billion iterations. This is 18,750 times larger than the largest sim Raidbots can currently handle.
In ideal cases, Raidbots can process about 100 low precision combinations per second - this is just the "first pass" phase where the error margin is quite high and so results are not precise. Give Raidbots current infrastructure, this would require just over 5 full days to complete and this is often the fastest stage of the sim.
There will be tools and UI provided that help target parts of a tree for simming but it will require a lot of tuning. I expect theorycrafters will be providing guides and guidance on low/high value talents that should help figure out what to focus on.